ea0044p13 | Adrenal and Steroids | SFEBES2016
Hunt Stephen
, Fritz Michele
, Schall William
, Bari Olivier N.
, Smedley Rebecca
, Pearson Paul
, Bailey Marc
, Langlois Daniel
Cushings syndrome (CS) in humans shares many similarities with its counterpart in dogs in terms of etiology (pituitary versus adrenal causes), clinical signs, and pathophysiologic sequelae. ATR-101 is a novel small molecule therapeutic currently in clinical development for the treatment of congenital adrenal hyperplasia and adrenocortical carcinoma in humans. ATR-101 is an adrenal-selective inhibitor of ACAT1 (acyl coenzyme A:cholesterol acyltransferase 1). ACAT1 catalyz...